London: Jo-Wilfried Tsonga joined the exodus of seeds at the Aegon Championships after being outplayed by Luxembourg's Gilles Muller at a boiling hot Queen's Club on Wednesday.
The Frenchman, seeded five, had no answer to left-hander Muller's swinging serve as he bowed out 6-4, 6-4.
Top seed and five-time champion Andy Murray, French Open runner-up Stan Wawrinka and 2016 Wimbledon runner-up Milos Raonic suffered surprise defeats on Tuesday.
Former champion Grigor Dimitrov was also in trouble when he lost the first set to French veteran Julien Benneteau but the sixth seed recovered to win 4-6, 6-3, 6-4 in one of the best matches of the tournament.
The Bulgarian gifted away an early break with a spate of double faults to give 35-year-old Benneteau the impetus.
But a superb lob followed by a Benneteau double-fault allowed Dimitrov to forge ahead in the second set and he was always in control thereafter, pulling off some crowd-pleasing diving volleys as he moved to victory.
"I started with three double-faults which is unlike me but I fought my way through the match and was composed," Dimitrov, who won the title in 2014, said.
The 34-year-old Muller won the grasscourt title in Den Bosch on Sunday and has continued that form on the London lawns. With on-court temperatures nudging 40 degrees Celsius, Tsonga looked as listless as the sweltering crowd as Muller dominated behind his serve to claim his second title of the year, having never won one before.
He needed one break in each set to subdue former runner-up Tsonga and will face either Murray's conqueror Jordan Thompson of Australia or American Sam Querrey in the quarterfinals.
"It's working well for me at the moment," Muller, who saved all three break points he faced, said.
"My serve is working great and it's good at this time of the year on the grass." American Donald Young also progressed, beating Serbia's Viktor Troicki in straight sets.