Health authorities in Hamas-run Gaza said at least 178 people had been killed by late Friday afternoon after the seven-day pause in fighting between the militants and Israel ended.
Officials said there were also 589 injuries recorded during the day.
DW cannot independently verify death tolls in the war.
Meanwhile, the Israel Defence Forces (IDF) said they had struck more than 200 Hamas targets after fighting resumed.
IDF spokesman Avichay Adraee wrote in Arabic on X, formerly Twitter, that airstrikes were carried out in Gaza's north and south, including in Khan Younis and Rafah.
The Qassam Brigades, the armed wing of Hamas, said it had fired several barrages of rockets toward Israel.
Qatar, a key mediator in the war, said it was committed to continuing efforts alongside its partners to secure another truce.
"Continuous bombardment of Gaza complicates mediation efforts and exacerbates humanitarian catastrophe," said Qatari Foreign Minister Sheikh Mohammed bin Abdulrahman Al Thani, in comments carried by the Reuters news agency.
UN says Israel will not renew top envoy's visa
Israel has told the United Nations it will not renew a visa for the top UN humanitarian aid official for Gaza and the West Bank.
Lynn Hastings, who is based in Jerusalem, has served as the deputy special coordinator for the Middle East peace process and UN humanitarian coordinator for the Occupied Palestinian Territory for almost three years.
"We've been informed by the Israeli authorities that they would not renew the visa of Miss Hastings past its due date at some point later this month," UN Secretary-General Antonio Guterres' spokesperson Stephane Dujarric told reporters in New York.
In late October, the Israeli Foreign Ministry criticized Hastings sharply on X, formerly Twitter, saying: "According to UN ethics, she is supposed to be impartial and objective, but unfortunately she is neither.
"Hastings' dangerous rhetoric endangers innocent Israeli and Palestinian civilians," the ministry wrote.
Dujarric did not mention the Israeli Foreign Ministry but said Hastings had faced some "public attacks" online that "were utterly unacceptable."
"The secretary-general is full confidence in Ms. Hastings, the way she's conducted herself and the way she's done her, her work, being the humanitarian coordinator in the occupied Palestinian territory is challenging work, to say the least, both in terms of the humanitarian situation — and the political situation," he added.